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Beg, S. and Akhter, S. (2021) Box-Behnken Designs and Their Applications in Pharmaceutical Product Development. In: Beg, S., Ed., Design of Experiments for Pharmaceutical Product Development, Springer, 77-85.
https://doi.org/10.1007/978-981-33-4717-5_7

has been cited by the following article:

• TITLE: Application of Box-Behnken Experimental Design in the Optimization of Cleaning Microfiltration Ceramic Filters Using Sodium Hydroxide

  AUTHORS: Ngiongboung Nguiamba, Celestine Asobo Yanu, Placide Désiré Belibi Belibi

  KEYWORDS: Chemical Cleaning, Ceramic Filters, Microfiltration, Box-Behnken, Optimization

  JOURNAL NAME: Journal of Materials Science and Chemical Engineering, Vol.12 No.12, December 13, 2024

  ABSTRACT: Chemical cleaning has been reported as the best method to restore ceramic filters flow rate by removing fouling agents. Even though there are several chemicals that can be used as cleaning agents, sodium hydroxide (NaOH) has been widely used as a cleaning agent. Literature reports that main factors of this cleaning are sodium hydroxide concentration, treatment temperature and contact time. However, the most significant factors have not been determined nor the interactions between them. The aim of this study was to determine the most significant parameter and the interactions between sodium hydroxide concentration, treatment temperature and contact time. This was done using Box-Behnken experimental design. The results, based on ANOVA analyses, showed that temperature is the most significant factor and that interaction between sodium hydroxide concentration and treatment temperature is the most significant interaction.