TITLE:
Liposomes Carrying Diclofenac Diethylammonium: A Penetrability and Permeation Study
AUTHORS:
Adriana Camino, Anyoli Taly, Cirana Rodriguez, Alfredo Inatti, Evelyn Pena, Xenon Serrano
KEYWORDS:
Liposomes, Diclofenac Diethylammonium, Transdermal Drug Delivery, Skin Permeation, Skin Penetration
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.12,
December
10,
2024
ABSTRACT: This study investigated whether liposomes could enhance the permeation and penetration of diclofenac diethylammonium. For this, a 1.16% diclofenac diethylammonium liposome gel formulation was developed (Grupo Leti, S.A.V.). In vitro and ex vivo tests were conducted to analyze the diffusion and penetration profiles of the formulation. The profiles obtained were compared with a commercially available product, DiAnalper gel (Pharmetique Labs). The in vitro test was assessed in a Franz diffusion cell system using a dialysis membrane. The cumulative amount of drug permeated after 24 h demonstrated a significantly (p 2, whereas the commercial formulation yielded values of 371.00 ± 3.54 μg/cm2. These findings were further supported by consistent results in the percentage of drug release, flux, and permeability coefficient, all indicating a notable improvement in diffusion associated with the liposomal gel formulation. The tape stripping assay performed on pig ear skin demonstrates a statistically significant difference (p