TITLE:
Evolution and Survival of Cirrhotic Patients with Kidney Failure at the CHU Campus in Lomé
AUTHORS:
Eyram Makafui Yoan Yawo Amekoudi, Kossi Akomola Sabi, Eugène Amétépé Attisso, Badomta Dolaama, Aklesso Bagny
KEYWORDS:
Togo, Survival, Renal Failure, Hepatic Cirrhosis, Etiological and Prognostic Factors
JOURNAL NAME:
Open Journal of Nephrology,
Vol.14 No.4,
December
4,
2024
ABSTRACT: Background: Renal failure in cirrhotic patients presents a significant complication that drastically affects survival rates, with factors like hepatorenal syndrome and other nephrotoxic conditions playing critical roles. Objective: To investigate the etiological and prognostic factors of renal failure in cirrhotic patients hospitalized in the Hepato-Gastroenterology department of the Lome University Hospital Center, and to assess the survival of these cirrhotic patients with renal insufficiency. Patients and Methods: Descriptive and analytical study conducted over 5 years (January 1, 2013 to December 31, 2017). Included were cirrhotic patients who had at least one serum creatinine value during hospitalization. Renal impairment was defined as a glomerular filtration rate (GFR) estimated by creatinine clearance 2. The statistical analysis was done with the R Studio software version 3.3.2. Results: A total of 210 patients were retained. Renal failure was found in 63 patients, with a prevalence of 30% [95% CI; 23.99% to 36.76%]. The sex ratio H/F was 0.46. The average age was 48.00 ± 14.36 years (range 18 - 95 years). Viral hepatitis B was predominant (40% of cases). Univariate and multivariate analysis showed that renal failure was associated with age > 46 years (p = 0.0035), ascites (p Conclusion: Etiologic and prognostic factors of renal failure in cirrhotic patients were age, ascites, hepatic encephalopathy stage 3, hypertension, hyperkalemia, diuretics, blood transfusion, and CHILD C. These patients have a decrease in their survival of 26.1% compared to those who do not have renal insufficiency. This makes kidney failure a prognostic factor for cirrhosis.