TITLE:
Therapeutic Potential of Berberine in Type 2 Diabetes: A Short Review
AUTHORS:
Maha Aldosari, Nehad Al-Shawi, Noorah Saleh Al-Sowayan
KEYWORDS:
Blood Glucose, Berberine, Insulin, Diabetes Mellitus, Cancer Cells, Oxidative Stress, Blood Vessels
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.17 No.11,
November
26,
2024
ABSTRACT: Background: Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease that is influenced by genetic, metabolic, and environmental factors. Genetic predisposition, obesity, low physical activity, and unhealthy diet are key risk factors for T2DM. Result: Type 2 diabetes is treated with various natural medicines, the most significant of which is berberine (BBR). Berberine, an isoquinoline alkaloid found in various medicinal plants, exhibits a wide range of pharmacological activities and (BBR) has the potential to treat various diseases, such as diabetes, cancer, and metabolic and cardiovascular diseases. Conclusion: It has been found to be effective in AMPK activation, regulation of blood glucose and lipids, stimulation of insulin secretion from pancreatic beta cells, inhibition of cancer cells, and reduction of fat formation.