TITLE:
Progress in the Study of Gene Mutations Associated with Papillary Thyroid Carcinoma
AUTHORS:
Jingjie Luo, Xin Dai, Xinyi Ren, Jinyu Zhang, Yuxin Zheng, Gang Cheng
KEYWORDS:
Papillary Thyroid Carcinoma, Gene Mutation, Diagnosis, Treatment, Prognosis
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.11,
November
20,
2024
ABSTRACT: In recent years, there has been a global rise in cases of papillary thyroid carcinoma (PTC), the predominant form of thyroid cancer. Advances in molecular biology have intensified the focus on the genetic mutations associated with this malignancy. Researchers have conducted extensive investigations into these mutations to elucidate their roles in the initiation, progression, treatment, and prognosis of PTC. This review synthesizes studies on the genetic mutations implicated in PTC, examining specific mutated genes, mechanisms of mutation, correlations with clinicopathological features, and their influence on treatment outcomes and prognosis. The objective is to provide a theoretical framework for enhancing the diagnosis, treatment, and prognostic assessment of PTC in the future.