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Riccio, I.R., LaForteza, A.C., Hussein, M.H., Linhuber, J.P., Issa, P.P., Staav, J., et al. (2024) Diagnostic Utility of RAS Mutation Testing for Refining Cytologically Indeterminate Thyroid Nodules. Excli Journal, 23, 283-299.

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• TITLE: Progress in the Study of Gene Mutations Associated with Papillary Thyroid Carcinoma

  AUTHORS: Jingjie Luo, Xin Dai, Xinyi Ren, Jinyu Zhang, Yuxin Zheng, Gang Cheng

  KEYWORDS: Papillary Thyroid Carcinoma, Gene Mutation, Diagnosis, Treatment, Prognosis

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.12 No.11, November 20, 2024

  ABSTRACT: In recent years, there has been a global rise in cases of papillary thyroid carcinoma (PTC), the predominant form of thyroid cancer. Advances in molecular biology have intensified the focus on the genetic mutations associated with this malignancy. Researchers have conducted extensive investigations into these mutations to elucidate their roles in the initiation, progression, treatment, and prognosis of PTC. This review synthesizes studies on the genetic mutations implicated in PTC, examining specific mutated genes, mechanisms of mutation, correlations with clinicopathological features, and their influence on treatment outcomes and prognosis. The objective is to provide a theoretical framework for enhancing the diagnosis, treatment, and prognostic assessment of PTC in the future.