TITLE:
Correlation between HbA1c and Extent of Mucormycosis Disease—A Prospective Observative Study
AUTHORS:
Siddharth Nirwan, Dhirendra Tak, Pawan Singhal, Anjali Bansal, Jitendra Kumar Jangir, Anshu Dev, Akshita Agarwal, Kailash Singh Jat, Anjani Kumar Sharma
KEYWORDS:
Mucormycosis, Immune-Compromised Patients, HbA1c Values
JOURNAL NAME:
International Journal of Otolaryngology and Head & Neck Surgery,
Vol.13 No.6,
November
18,
2024
ABSTRACT: Background: Prognosis in Mucormycosis is poor, secondary to the nature of such opportunistic angioinvasive fungal infection that affects immuno-compromised patients with uncontrolled diabetes which is a common risk factors in most of the cases. Objectives: Patients with post-Covid Mucormycosis presenting to the ENT OPD were included and evaluated for HbA1c, extent of disease, and subsequently underwent the required modality of management. Methods: A prospective observational study was done in 154 patients of mucormycosis and according to the extent of disease such as sinonasal involvement, orbital extension or intracranial extension, the HbA1c values were compared among themselves. Results: In our study, out of 154 patients, 86 (55.8%) patients have only sinonasal involvement, 30 (19.4%) patients have extension into orbit and 38 (24.6%) patients have intracranial spread. In patients with sinonasal involvement, mean HbA1c was 9.8 ± 2.41; in orbital extension, mean HbA1c was 12.7 ± 2.31 and in intracranial extension, mean HbA1c was 13.4 ± 1.98. Conclusion: In our study, elevated HbA1c is indicative of poor glycaemic control and positively correlated with increased invasiveness and aggressive fungal disease.