TITLE:
Costello Syndrome and Transitional Cell Carcinoma of Bladder
AUTHORS:
Wasiem Abo Nassra
KEYWORDS:
Costello, Pediatric, Children, Transitional Cell Carcinoma
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.14 No.6,
November
15,
2024
ABSTRACT: Costello syndrome is a rare neurodevelopmental disorder (RASopathy) caused by activating germline mutation in HRAS. Due to ubiquitous HRAS gene expression, Costello Syndrome affects multiple organ systems and individuals are predisposed to cancer. A male patient, at 13 years of age, had a suspicion of two small findings in the bladder after he had a history of dysuria and microscopic hematuria by two urine analyses. Both were completely resected and the pathology revealed Fibroepithelial polyps. The patient was followed up by an ultrasound of the bladder every six months.