TITLE:
New Triterpenoid Isolated from the Roots of Gouania longipetala Hemsl
AUTHORS:
Anderson Claver Kimou, Kouamé Jean-Michel Koffi, Seri Chardin Seri, Zachée Louis Evariste Akissi, Kurouindé Viviane Nemlin, Akoua Philomène Yao-Kouassi, Laurence Voutquenne-Nazabadioko
KEYWORDS:
Gouania longipetala, Rhamnaceae, Lupane-Type Triterpenoids
JOURNAL NAME:
Open Journal of Applied Sciences,
Vol.14 No.11,
November
13,
2024
ABSTRACT: Gouania longipetala Hemsl. (Rhamnaceae) is a medicinal plant from Côte d’Ivoire used to treat many diseases like malaria, gastrointestinal infections and gout. Scientific research of aerial part revealed the presence of triterpenoid compounds, saponins, phenolic compounds and flavonoids and also mentioned antibacterial, antioxydant and anti-inflammatory activities. Despite the various therapeutic uses of the plant, no scientific research mentions the chemical content of the root. So, this phytochemical investigation is made to identify secondary metabolites present in the hydromethanolic extract of its roots. And the research led to the isolation and characterization of three lupane-type triterpenoid compounds: a novel compound derived from gouanic acid, lupeol (1) and betulin (2), which had been previously reported in the literature. The newly discovered lupane-triterpenoid was identified as 1α-hydroxy-lup-20(29)-en-3-oxo-27,28-dioic acid (3). The structures of these compounds were determined based on analyses of spectroscopic data, including 1D-NMR, 2D-NMR and HR-ESI-MS techniques.