TITLE:
Research Progress on Multidisciplinary Intervention for Metabolic Dysfunction-Associated Steatotic Liver Disease and Related Liver Cancer
AUTHORS:
Yu Zhang, Chao Xu
KEYWORDS:
Non-Alcoholic Fatty Liver Disease, Metabolic Dysfunction-Associated Steatotic Liver Disease, Hepatocellular Carcinoma, Metabolic Syndrome, Multidisciplinary, Intervention
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.11,
November
11,
2024
ABSTRACT: In recent years, non-alcoholic fatty liver disease (NAFLD) has developed rapidly worldwide and has become the main cause of chronic liver disease. With the increase in prevalence, the incidence of NAFLD-related hepatocellular carcinoma (HCC) has increased sharply. These patients are often diagnosed late, have a poor prognosis, and there is still a lack of corresponding intervention measures. The close connection between NAFLD and metabolic comorbidities has given rise to a new name, “Metabolic dysfunction-associated steatotic liver disease” (MASLD), which provides us with new intervention ideas to curb the progression of liver disease through the common intrinsic mechanisms related to regulating metabolic conditions through multidisciplinary combined treatment of early metabolic comorbidities. This review analyzes the clinical status of NAFLD/MASLD and the intrinsic relationship with related metabolic syndrome, explores the potentially beneficial interventions for MASLD and related HCC in multidisciplinary treatment, including some commonly used clinical drugs, deepens the understanding of the disease and provides references for prevention and intervention.