TITLE:
Ovarian Reserve in a Population of Obese Infertile Patients in Kinshasa
AUTHORS:
Charlie-Junior Bikuelo Bikuelo, Dan Ngoyi Kabengele, Justin Mboloko Esimo, Athéna Mwakila Asana, Guy Monzango Sibo, Charles Moangi Bapanzi, Patrick Mogwo Sendeke, Pathou Mampuya Ipanga, Annie Egbolo Azima
KEYWORDS:
Ovarian Reserve, Obesity, Infertility, AMH, FSH
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.14 No.10,
October
29,
2024
ABSTRACT: Background: The ovarian reserve, which is an important marker in the management of couple infertility, undergoes depletion over time. This depletion could accelerate in the presence of certain circumstances, such as obesity. The contradictory results of studies on the impact of obesity on the ovarian reserve throughout the world accelerated ovarian ageing in infertile women from Kinshasa, as well as the high rate of obese women in this population, seemed necessary to undertake this study to find out if this obesity impacted the ovarian reserve of Kinshasa women. The objective of this study was to identify the profile of markers of ovarian reserve in obese infertile patients according to certain characteristics. Method: A case-control study with retrospective data collection on 439 obese infertile patients (cases) and 439 normal-weight infertile patients (controls) who had consulted for the desire to conceive at the University Hospital of Kinshasa and the Edith Medical Center between January 2016 and December 2021. Results: The average age of the patients was 33.6 years ± 4.3 years, with 47.8% of patients aged at least 35 years. Menarche and menstrual duration were correlated with AMH in linear regression (p = 0.043 and 0.021, respectively). Late menarche and irregular cycle were risk factors for ovarian ageing [OR: 4.6; 95% CI: (1.052 - 20.636); p = 0.043 and OR: 4.8; 95% CI: (1.633 - 14.566); p = 0.005] while PCO was a protective factor for ovarian ageing [OR: 0.109; 95% CI: (0.182 - 0.652); p = 0.015]. Conclusion: Within the limits of our study, we found that the more obese the patients were, the faster the ovaries aged.