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Sang, Y., Liu, Q., Lee, J., Ma, W., McVey, D.S. and Blecha, F. (2016) Expansion of Amphibian Intronless Interferons Revises the Paradigm for Interferon Evolution and Functional Diversity. Scientific Reports, 6, Article No. 29072.
https://doi.org/10.1038/srep29072

has been cited by the following article:

• TITLE: Virus-Encoded MicroRNAs Reveal How Ranavirus Interacts with Amphibian Immune Defense

  AUTHORS: Aaron Yang

  KEYWORDS: Ranaviruses, Amphibians, Virus-Encoded MicroRNA, Frog Virus 3, Virus-Host Interaction

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.17 No.10, October 22, 2024

  ABSTRACT: Ranaviruses are harmful viruses that infect amphibians, fish, and reptiles, and have caused particularly devastating declines in amphibian populations. One particular type of ranavirus, called Frog Virus 3 (FV3), has been extensively studied due to its prevalence and impact on amphibians. Previous research has primarily focused on the virus’s genes, but little attention has been given to the non-coding regions of its genome. This article reviews recent studies that reveal the ability of ranaviruses, including FV3, to encode microRNA (miRNA), a type of regulatory RNA. These viral miRNAs play a crucial role in suppressing frog immune genes, modulating the virus-host interaction, and promoting viral infection. Understanding how ranaviruses use miRNAs to control disease progression is essential for addressing the health threat they pose to wildlife and ecosystems.