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Lake, D.E., Richman, J.S., Griffin, M.P. and Moorman, J.R. (2002) Sample entropy analysis of neonatal heart rate variability. American Journal of Physiology— Regulatory, Integrative and Comparative Physiology, 283(3), 789-797.

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• TITLE: A new approach for epileptic seizure detection: sample entropy based feature extraction and extreme learning machine

  AUTHORS: Yuedong Song, Pietro Liò

  KEYWORDS: Epileptic Seizure; Electroencephalogram (EEG); Sample Entropy (SampEn); Backpropagation Neural Network (BPNN); Extreme Learning Machine (ELM); Detection

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.3 No.6, June 25, 2010

  ABSTRACT: The electroencephalogram (EEG) signal plays a key role in the diagnosis of epilepsy. Substantial data is generated by the EEG recordings of ambulatory recording systems, and detection of epileptic activity requires a time-consuming analysis of the complete length of the EEG time series data by a neurology expert. A variety of automatic epilepsy detection systems have been developed during the last ten years. In this paper, we investigate the potential of a recently-proposed statistical measure parameter regarded as Sample Entropy (SampEn), as a method of feature extraction to the task of classifying three different kinds of EEG signals (normal, interictal and ictal) and detecting epileptic seizures. It is known that the value of the SampEn falls suddenly during an epileptic seizure and this fact is utilized in the proposed diagnosis system. Two different kinds of classification models, back-propagation neural network (BPNN) and the recently-developed extreme learning machine (ELM) are tested in this study. Results show that the proposed automatic epilepsy detection system which uses sample entropy (SampEn) as the only input feature, together with extreme learning machine (ELM) classification model, not only achieves high classification accuracy (95.67%) but also very fast speed.