TITLE:
Assay Advancements: Exploring Varied Assays for Thyroid-Stimulating Hormone Measurement in Subclinical Hypothyroidism Diagnosis in Riyadh, Saudi Arabia
AUTHORS:
Qumasha Alobaid, Sumayah Aljenedil, Waleed Altamimi, Khalid Alsumaily
KEYWORDS:
Immunoassays, Subclinical Hypothyroidism, Thyroid Stimulating Hormone
JOURNAL NAME:
Open Journal of Medicinal Chemistry,
Vol.14 No.4,
October
21,
2024
ABSTRACT: Thyroid-stimulating hormone (TSH) assay is considered a decisive diagnostic method for thyroid disorders. The lack of different TSH immunoassay standardization often leads to misdiagnosis of subclinical hypothyroidism (SCH). This study aims to differentiate between two analytical platforms for TSH measurement, namely Abbott Laboratories and Snibe Diagnostics. This study employed 173 thyroid profile samples to detect SCH. Initially, the sample was run on Abbott and then by Snibe immunoassay. Statistical analysis showed a significant difference of 0.87 mIU/L (P