TITLE:
The Value of γδ T Cells in Lung Infections and Advances in Diagnosis and Treatment
AUTHORS:
Jiyu Xiao, Wei Wang, Yuqing Weng
KEYWORDS:
Lung Infections, γδ T Cells, Immunotherapy, IL-17
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.10,
October
16,
2024
ABSTRACT: Lung infections are usually caused by pathogenic microorganisms and are a disease with high morbidity and mortality. In clinical practice, the use of broad-spectrum antibiotics has become increasingly common, but this has also led to the problem of antibiotic abuse and irrational use, which in turn has spawned the emergence of multidrug-resistant bacteria, making the treatment of lung infections more complex and difficult. In the human immune system, γδ T cells play a crucial role in defense against foreign pathogens and regulation of autoimmune responses. These cells act as a bridge between innate and adaptive immunity and can be rapidly activated in the early stages of infection to produce inflammatory factors and chemokines that attract other immune cells to the site of infection. Recent advances have shown that γδ T cells not only play a direct role in the innate immunity of pathogen infection, but are also involved in regulating the subsequent adaptive immune response. The aim of this review is to explore the mechanism of γδ T cells in lung infections and to summarize the current progress of clinical research, with the aim of providing new scientific basis and therapeutic strategies for the treatment of lung infections.