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P. Yilgor, K. Tuzlakoglu, R. L. Reis, N. Hasirci and V. Hasirci, “Incorporation of a Sequential BMP-2/BMP-7 Delivery System into Chitosan-Based Scaffolds for Bone Tissue Engineering,” Biomaterials, Vol. 30, No. 21, 2009, pp. 3551-3559. doi:10.1016/j.biomaterials.2009.03.024

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• TITLE: Multidrug Delivery Systems with Single Formulation——Current status and Future Perspective

  AUTHORS: Tatsuya Okuda, Satoru Kidoaki

  KEYWORDS: Multidrug Delivery System; Single Formulation; Combination Therapy; Biochemical Modulation

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.3 No.1, December 31, 2011

  ABSTRACT: Development of new way and system for multidrug delivery has recently attracted much attention and became one of major issue in drug delivery research. Although this research field is still immature compared to the single drug delivery system, intensive efforts have recently been devoted by researchers in order to realize more efficient, functional, and safe combination therapy using multiple drugs or agents. In this review article, we outline several targets in terms of application for biochemical modulation together with various concrete attempts of simultaneous and sequential delivery of multiple drugs or agents with single formulation. Finally, we will also summarize the possible contribution of biomaterial sciences and nanobiotechnology for improvement of future multidrug delivery system.