TITLE:
Cyclopia Associated with Sexual Ambiguity Discovered at the Birth of a Newborn Whose Mother Contracted COVID-19 in Early Pregnancy: A Rare Case at the Teaching Hospital of Angre (ABIDJAN)
AUTHORS:
Koffi Soh Victor, Adjoby Cassou Roland, Effoh N’drin Denis, Kouakou-Kouraogo Ramata, Akobé Privat, Loba Okoin Paul José, Houphouet-Mwandji Blanche Carine
KEYWORDS:
Cyclopia, Holoprosencephaly, Congenital Malformation, COVID-19
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.14 No.10,
October
15,
2024
ABSTRACT: Cyclopia is a rare congenital brain malformation frequently associated with facial anomalies. It is characterized by the presence of a single eye with varying degrees of doubling of the intrinsic ocular structures located in the middle of the face. It is the most severe facial expression of holoprosencephaly. Its aetiology is still poorly understood, but several factors could play a role in its occurrence, including certain viruses contracted during pregnancy. Obstetrical ultrasound has made antenatal diagnosis and the search for associated malformations possible. This diagnosis must be made antenatally because the prognosis is poor, hence the decision to terminate the pregnancy. We report a case of cyclopia associated with ambiguity of the external genitalia, discovered intraoperatively in a patient with poor prenatal follow-up, in whom a coronavirus infection (COVID-19) had been diagnosed in early pregnancy.