TITLE:
Endogenous Endophthalmitis as a Triggering Factor for Fatal Bacterial Meningitis Caused by Streptococcus pneumoniae: A Case Report
AUTHORS:
David Fernando Ortiz-Pérez, Mario Enrique Montoya-Jaramillo, Juan Pablo de la Ossa Díaz, Natalia Vanessa Benavides-Garzón, Luis Augusto Martínez-Aguilera, Luis Miguel Orozco-Pabón, Santiago José González-Manzur, Víctor Santiago Márquez-Camacho, Miguel Gregorio Tordecilla-Castro, Gustavo Alberto Gutiérrez Barros, John Sebastián Osorio-Muñoz
KEYWORDS:
Central Nervous System Infections, Meningitis, Infectious Disease Medicine, Endogenous Endophthalmitis
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.10,
October
15,
2024
ABSTRACT: Endogenous endophthalmitis is a rare condition with a poor long-term visual prognosis and significant mortality, often associated with the hematogenous spread of intravitreal infections and subsequent disruption of the blood-ocular barrier. Its anatomical proximity to the central nervous system (CNS) poses a high risk of infection dissemination, although cases documented in the literature are rare, and endogenous endophthalmitis is typically described as secondary to neuroinfections. We report the case of an 82-year-old female patient with a history of hypertension who presented with fever, decreased visual acuity, severe headache, chemosis, and conjunctival injection. Endogenous endophthalmitis was diagnosed, and antimicrobial treatment was initiated alongside surgical intervention by the ophthalmology service. However, the patient’s condition worsened neurologically, and Streptococcus pneumoniae was identified in cerebrospinal fluid cultures. Despite intensive medical treatment, the patient’s clinical course was poor, leading to death.