TITLE:
Assessment of Renal Erythropoietic Status of the Newly Diagnosed Diabetic Patients without Renal Impairment in Benin City, Nigeria
AUTHORS:
Grace Umahi-Ottah, Osehimimhen Precious Inegbedion, Ojo Moses Oke, Usman Itakure Abdulkadir, Nkechi Augustina Olise, Adewale Adegboyega Oke, Emmanuel Ojeideleko Akhaumere, Uche Cletus Odionyenma, Fidelis Ohiremen Oyakhire, Iria Kelly Esezobor, Samson Efenarhua, Chinemerem Elizabeth Anwara, Osamudiamen Joshua Eboselume, Simon Uzor, Babatunde Ishola Gabriel Adejumo
KEYWORDS:
Erythropoietin, Renal, Diabetes, Urea, Creatinine, Electrolytes
JOURNAL NAME:
Health,
Vol.16 No.10,
October
12,
2024
ABSTRACT: Diabetes mellitus is a carbohydrate metabolism disorder which is caused due to impairment in insulin secretion and/or the activity of insulin, leading to chronic hyperglycemia with defective carbohydrate, fat and protein metabolism. This study aimed at assessing the erythropoietin (EPO), hemoglobin and renal parameters levels among the newly diagnosed diabetic patients and providing valuable insights into the management and progression of the disease. A case-control study was conducted on samples of 60 consenting participants including newly diagnosed diabetic patients (n − 30), and healthy controls (n − 30) of age ranging between 20 - 50 years. EPO level was measured using enzyme-linked immunosorbent assay (ELISA), the renal parameters (electrolytes) were measured using Ion-Selective Electrodes. Hemoglobin, urea and creatinine were measured using cyanmethemoglobin and colorimetric methods respectively under standard protocols. Demographic and clinical data, including age, gender, diabetes duration, iron rich diet consumption, medication history and family history were collected via questionnaires. Independent sample t-test indicated significantly higher mean hemoglobin (p