TITLE:
The Role of NF-κβ and HIF-1α in the Formation of Deep Vein Thrombosis
AUTHORS:
Erchang Zhu, Yueqiu Liu, Lei Li
KEYWORDS:
DVT, NF-κβ, HIF-1α, Inflammation, Biomarker
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.9,
September
29,
2024
ABSTRACT: Deep vein thrombosis (DVT) remains a significant clinical challenge, with complex underlying pathophysiological mechanisms. Among the myriad factors contributing to DVT, the transcription factors NF-κβ and HIF-1α have been increasingly recognized for their roles. This study aims to deepen the understanding of NF-κβ and HIF-1α in the pathogenesis of DVT and explore potential therapeutic implications. This research investigates the expression of NF-κβ and HIF-1α in patients with DVT compared to a healthy control group, utilizing ELISA techniques for quantification. The results of the study showed that the expression of NF-κβ and HIF-1α in the blood samples of patients with DVT was significantly higher than that of normal subjects, and the difference was statistically significant (P κβ and HIF-1α in the peripheral blood of DVT patients, suggesting their critical roles in inflammation and hypoxia regulation, with potential for future research into their mechanisms and therapeutic applications.