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Li, Y., Ge, J., Ma, K., Yin, Y., He, J. and Gu, J. (2022) The Combination of EGCG with Warfarin Reduces Deep Vein Thrombosis in Rabbits through Modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 Signaling Pathways. Chinese Journal of Natural Medicines, 20, 679-690. https://doi.org/10.1016/s1875-5364(22)60172-9

has been cited by the following article:

• TITLE: The Role of NF-κβ and HIF-1α in the Formation of Deep Vein Thrombosis

  AUTHORS: Erchang Zhu, Yueqiu Liu, Lei Li

  KEYWORDS: DVT, NF-κβ, HIF-1α, Inflammation, Biomarker

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.12 No.9, September 29, 2024

  ABSTRACT: Deep vein thrombosis (DVT) remains a significant clinical challenge, with complex underlying pathophysiological mechanisms. Among the myriad factors contributing to DVT, the transcription factors NF-κβ and HIF-1α have been increasingly recognized for their roles. This study aims to deepen the understanding of NF-κβ and HIF-1α in the pathogenesis of DVT and explore potential therapeutic implications. This research investigates the expression of NF-κβ and HIF-1α in patients with DVT compared to a healthy control group, utilizing ELISA techniques for quantification. The results of the study showed that the expression of NF-κβ and HIF-1α in the blood samples of patients with DVT was significantly higher than that of normal subjects, and the difference was statistically significant (P κβ and HIF-1α in the peripheral blood of DVT patients, suggesting their critical roles in inflammation and hypoxia regulation, with potential for future research into their mechanisms and therapeutic applications.