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Gangavati, A., Hajjar, I., Quach, L., Jones, R.N., Kiely, D.K., Gagnon, P., et al. (2011) Hypertension, Orthostatic Hypotension, and the Risk of Falls in a Community-Dwelling Elderly Population: The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly of Boston Study. Journal of the American Geriatrics Society, 59, 383-389.
https://doi.org/10.1111/j.1532-5415.2011.03317.x

has been cited by the following article:

• TITLE: Orthostatic Hypotension: QTc Interval Prolongation during Head-Up Tilt

  AUTHORS: Gabriel Vanerio, Maria Jose Arocena

  KEYWORDS: Syncope, Orthostatic Hypotension, QTc Interval, Reflex Syncope, Autonomic Nervous System

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.15 No.9, September 29, 2024

  ABSTRACT: Background: The QT interval shortens in response to sympathetic stimulation. Head-up tilt-table (HUT) testing is a straightforward way to achieve brisk sympathetic stimulation. There is not enough information about the response of the QT interval to HUT, particularly, in patients with orthostatic hypotension (OH). Objective: Analyse the response of the RR, QT and QTc intervals in patients with OH and reflex syncope (NM) during HUT and find differences between groups. Methods: We reviewed the electrocardiograms and compare the RR and QT/QTc intervals during 1) baseline; 2) HUT plus hyperventilation; 3) positive test. Results: We studied 137 patients, 62 control group (no syncope and negative HUT). On average, the RR HUT interval was shorter than the resting RR by −171 ± 110.4 ms in controls; −228.6 ± 119.4 ms (NM) and −194 ± (OH) (P Conclusion: Significant differences between the reflex group and the OH during a positive test, the QTc decreased in the NM group, but in the OH population increased. This observation has not been described. We hypothesize that QTc prolongation could reflect autonomic nervous system downregulation and could explain to a degree, the increased mortality in this group.