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Tsuji, H., Nakashima, R., Hosono, Y., Imura, Y., Yagita, M., Yoshifuji, H., et al. (2020) Multicenter Prospective Study of the Efficacy and Safety of Combined Immunosuppressive Therapy with High‐Dose Glucocorticoid, Tacrolimus, and Cyclophosphamide in Interstitial Lung Diseases Accompanied by Anti-Melanoma Differentiation-Associated Gene 5-Positive Dermatomyositis. Arthritis & Rheumatology, 72, 488-498.
https://doi.org/10.1002/art.41105

has been cited by the following article:

• TITLE: Anti-MDA-5 Positive Clinically Amyopathic Dermatomyositis Associated with Rapidly Progressive Interstitial Lung Disease Presenting as Spontaneous Pneumomediastinum

  AUTHORS: Boon Hau Ng, Mohamed Fathimath, Hsueh Jing Low, Nik Nuratiqah Nik Abeed, Nor Safiqah Sharil, Rose Azzlinda Osman, Mohd Imree Azmi, Andrea Yu-Lin Ban

  KEYWORDS: Interstitial Lung Disease, Pneumomediastinum, Anti-MDA5 Antibody

  JOURNAL NAME: Open Access Library Journal, Vol.11 No.9, September 26, 2024

  ABSTRACT: Spontaneous pneumomediastinum (SPM) is a rare complication of anti-melanoma differentiation-associated protein 5 (MDA5) positive clinically amyopathic dermatomyositis (CADM). Herein, we report an elderly patient presented with cutaneous signs and SPM. Serial workup confirmed the anti-MDA5 positive CADM. Treatment initially included methylprednisolone, cyclosporine, and cyclophosphamide, but recurrence led to the use of rituximab and mycophenolate mofetil, ultimately resolving the pneumomediastinum and stabilisation of the lung functions. This underscores the importance of promptly recognising and managing pneumomediastinum in the context of anti-MDA5 positive CADM-associated rapid interstitial lung disease (RP-ILD).