TITLE:
Prediction of the Photofading of Selected Derivatives of 5-(4-X-Phenylazo)-3-Cyano-1-(H or Ethyl)-6-Hydroxy-4-Methyl-2-Pyridone: Theoretical Studies, Comparison of AM1 and PM3 Methods
AUTHORS:
Krzysztof Wojciechowski, Lucjan Szuster
KEYWORDS:
Photochemical Degradation, AM1 and PM3 Methods, Boundary Orbitals Electron Densities, Electrophilic and Nucleophilic Reaction, HOMO and LUMO Orbitals
JOURNAL NAME:
Computational Chemistry,
Vol.12 No.2,
April
30,
2024
ABSTRACT: We analysed the photooxidation reaction in the electro-(1O2) and nucleophilic (
O
2
•−
) reaction of 2-pyridone azo derivatives. First, we calculated the energy (enthalpies) of tautomers formation, which is a measure of durability and the probability of their formation. We performed the light fastness calculations of the monoazopyridone dyes. Using the semi-empirical methods of quantum chemistry AM1 and PM3, the reactivity indicators of superdelocalisability (
S
r
E(
N
)
) and the electron density distribution in ground state on the highest occupied HOMO orbital and the lowest unoccupied excited state LUMO in 2-pyridone phenylazo derivatives were calculated. Superdelocalisability coefficients enable the stability to oxidising agents of various chemical molecules depending on the tautomeric forms in which they may occur. The results of the electron density calculations at the HOMO and LUMO boundary orbitals allow to determine the tendency to electrophilic attack with singlet oxygen 1O2 or nucleophilic attack of the superoxide anion
O
2
•−
on a specific atom in the molecule. The structure of the dyes was optimised with MM+, MD and AM1 or PM3 until a constant energy value was achieved with a convergence criterion of 0.01 kcal/mol.