TITLE:
Research Progress on Brain-Derived Neurotrophic Factor (BDNF) in the Sequelae of Stroke
AUTHORS:
Fuzhou Xie, Weicong Chen, Longjian Huang
KEYWORDS:
Brain-Derived Neurotrophic Factor, Sequelae of Stroke, Neurorehabilitation
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.9,
September
25,
2024
ABSTRACT: The research progress of brain-derived neurotrophic factor (BDNF) in the treatment of sequelae of stroke is an important topic. Stroke is among the diseases with the highest mortality and disability rates among the elderly in China. BDNF plays an important role in the development and functional maintenance of the nervous system. In recent years, the application value of BDNF in rehabilitation therapy has gradually received attention. This study has adopted a systematic literature review method, searched Chinese and English databases, screened relevant studies, and conducted data extraction and quality evaluation. This review systematically introduced the research progress of BDNF in the correlation with post-stroke sequelae, with special attention to its application in post-stroke depression, motor dysfunction, and cognitive dysfunction. The results showed that a decrease in BDNF levels is closely related to the exacerbation of depressive symptoms, limited recovery of motor dysfunction, and the occurrence of cognitive dysfunction. BDNF, as a key neurobiological factor, has shown significant potential in the rehabilitation treatment of stroke. By exploring the potential of BDNF as a therapeutic target to prevent and treat sequelae of ischemic stroke, the current research bottlenecks, and the development trends of future treatment strategies.