TITLE:
Preliminary Study on Occult Hepatitis B in Sickle Cell Anemia
AUTHORS:
Maurice Mambu Kalonji, Steve Dibere Kodondi, Bijou Tsholuka Bondo, Blaise Matondo Manzambi Sumbu, Paulin Beya Mutombo, Guylain Kawali Nyembo, Excellence Ngbo Tongu, Mireille Lelo Babazanga, Caddy Nsenga Ngoie, Tite Minga Mikobi, Fridolin Kule Koto Kodondi, Steve Mundeke Ahuka
KEYWORDS:
Occult Hepatitis B, Sickle Cell Disease, Transfusion, Elisa, Determine
JOURNAL NAME:
Open Access Library Journal,
Vol.11 No.9,
September
25,
2024
ABSTRACT: Introduction: The transmission of occult hepatitis B Virus (HBV) is a significant public health issue among transfused sickle cell disease (SCD) patients. Object: The aim of this study was to determine the prevalence of occult hepatitis B in SCD patients and to establish the association between HBsAg and anti HBc, according to the number of blood transfusions received. Patients and Methods: This epidemiological, descriptive and analytical study was conducted in three sickle cell care centers in Kinshasa from January to June 2018, involving 384 transfused SCD patients. Results: The study revealed that the age group 10 - 20 years was the most represented with a predominance of males (male-female sex ratio of 1.07). 65 patients of the study population tested positive for anti-HBc but negative for HbsAg and had occult hepatitis, representing 19.0 % of the total Conclusion: Occult hepatitis B is a particular form of HBV infection that is increasingly attracting the attention of clinicians in the SCD patients.