TITLE:
Antinociceptive Effect of Ethanolic Extract of Codiaeum variegatum Leaves in Mice
AUTHORS:
Md. Asrafuzzaman, Ambia Khatun, Md. Abdul Mannan
KEYWORDS:
Codiaeum variegatum, Extract, Phytochemistry, Antinociceptive
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.15 No.9,
September
12,
2024
ABSTRACT: Background: Codiaeum variegatum, sometimes called garden croton, is a tropical plant in the Euphorbiaceae family. Historically used to cure various conditions, including intestinal infections, fever, ulcers, wounds, and gonorrhea. This work aimed to investigate the antinociceptive effects of ethanolic extract of Codiaeum variegatum leaves (EECV) in animal models. Methods: Five different pain models—the hot plate, tail immersion, acetic acid-induced writhing, formalin, and glutamate-induced nociception tests—were utilized to assess the antinociceptive activity in mice. The traditional drugs such as diclofenac sodium (10 mg/kg, i.p.) and morphine sulphate (5 mg/kg). EECV was administered orally at varying doses of 100, 200, and 300 mg/kg (0.1 mL/mouse), while the control group was given deionized water. Results: The current study found that all mouse models of heat- and chemical-induced pain had robust EECV reflections of their antinociceptive properties (*p Conclusions: The current finding offers a fresh perspective on the ethanolic extract of Codiaeum variegatum leaves’ antinociceptive properties in mice. This plant’s phytochemical analysis revealed the presence of triterpenoids, sterols, alkaloids, flavonoids, and general glycosides, all of which may have antinociceptive properties. More research on the mechanism of action and associated pharmacological studies, such as in vivo analysis, medication formulation, and clinical trials, is strongly advised.