TITLE:
The Regulation of Slow-Wave Sleep on Growth Hormone Secretion and Homeostatic Aging: A Pure Model in Man
AUTHORS:
Zi-Jian Cai
KEYWORDS:
Growth Hormone, Slow-Wave Sleep, Depression, Homeostatic Aging, Evolution
JOURNAL NAME:
Open Access Library Journal,
Vol.11 No.9,
September
4,
2024
ABSTRACT: Introduction: It is complicated for regulation of growth hormone (GH) secretion. Herein, it is considered the effects of slow-wave sleep (SWS) on GH secretion and related homeostatic aging, and their implications to other complicated GH secretions. Methods: It was best and most convincing to integratively review the literatures in various fields, especially the relationship among GH, SWS, aging, evolution, etc., and then discuss and summarize to deal with such a complicated topic. Results and Discussions: 1) With various pharmacological manipulations of SWS demonstrating the congruent change of GH secretion following SWS in man, it is defined such SWS regulation on GH secretion as pure model. 2) On aging, it is congruent in senescent reduction of both SWS and GH secretion in man. 3) It occurs the complicated GH secretions beyond the period of SWS, notably in woman and depression, rhesus monkeys and dogs. It was shown in woman the estrogen facilitated the endogenous GH release, so was in depression the growth hormone-releasing hormone (GHRH) along with reduced somatostatin before sleep onset. 4) In evolution, it has been suggested the various GH secretions across vertebrates manifest an evolutionary trend for simplification in factors for secretion regulation. Conclusions: It is feasible to classify various forms of GH secretion and related aging as either compatible or incompatible with the pure model in man, making it convenient to investigate their underlying mechanisms including satiety, estradiol, etc.