TITLE:
Efficacy of a Diabetes Specific Nutrition Supplement on Glycemic, Anthropometric, Dietary and Gut Health Markers in Adults with Type 2 Diabetes: An RCT
AUTHORS:
Deepti Khanna, Hema S. Gopalan, Kuzhandaivelu Abirami, Vasudevan Sudha, Rajagopal Gayatri, Kejal Joshi-Reddy, Jaladhi Bhatt, Raman Ganesh Jeevan, Karthikeyan Parkavi, Vadivel Deepika, Manoj Pareek, Ranjit Mohan Anjana, Viswanathan Mohan
KEYWORDS:
Diabetes Specific Nutrition Supplement, Standard of Care, Diabetes, Glycemic Markers, HbA1C
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.15 No.8,
August
30,
2024
ABSTRACT: With increasing incidence of diabetes, use of diabetes specific nutrition supplements (DSNS) is common for better management of the disease. To study effect of 12-week DSNS supplementation on glycemic markers, anthropometry, lipid profile, SCFAs, and gut microbiome in individuals with diabetes. Markers studied were glycemic [Fasting Blood Glucose (FBG), Post Prandial Glucose (PPG), HbA1c, Incremental Area under curve (iAUC), Mean Amplitude of Glycemic Excursions (MAGE), Time in/above Range (TIR/TAR)], anthropometry [weight, Body Mass Index (BMI), waist circumference (WC)], lipid profile, diet and gut health [plasma short chain fatty acids (SCFAs)]. N = 210 adults were randomized to receive either DSNS with standard care (DSNS + SC; n = 105) or standard care alone (SC alone; n = 105). After 12 weeks, significant differences between DSNS + SC versus SC alone was observed in FBG [−3 ± 6 vs 14 ± 6 mg/dl; p = 0.03], PPG [−35 ± 9 vs −3 ± 9 mg/dl; p = 0.01], weight [−0.6 ± 0.1 vs 0.2 ± 0.1 kg; p = 0.0001], BMI [−0.3 ± 0.1 vs 0.1 ± 0.1 kg/m2; p = 0.0001] and WC [−0.3 ± 0.2 vs 0.2 ± 0.2 cm; p = 0.01]. HbA1C and low-density lipoprotein (LDL) were significantly reduced in DSNS + SC [−0.2 ± 0.9; p = 0.04 and −5 mg/dl; p = 0.03] respectively with no change in control. Continuous Glucose Monitoring (CGM) reported significant differences between DSNS + SC versus SC alone for mean glucose [−12 ± 65 vs 28 ± 93 mg/dl; p