TITLE:
Feasibility Study of Neurofeedback Therapy for Alzheimer’s Disease
AUTHORS:
Ruyu Li, Min Yang
KEYWORDS:
Alzheimer’s Disease, Brain-Computer Interface, Neurofeedback, Cognitive Function, Disruptive Behaviors
JOURNAL NAME:
Advances in Alzheimer's Disease,
Vol.13 No.3,
August
29,
2024
ABSTRACT: Objective: This study aims to evaluate the feasibility and effectiveness of neurofeedback therapy based on brain-computer interface (BCI) games in enhancing cognitive functions and reducing disruptive behaviors in patients with Alzheimer’s disease (AD). Methods: Forty-six AD patients aged 49 - 76 years were recruited for the study. Neurofeedback regulation was conducted using a BCI game designed to modulate EEG rhythms. Cognitive function was assessed using MMSE, MoCA, and ADAS-cog scales before and after a 10-day training period. EEG measurements were taken to evaluate changes in brain activity complexity. Statistical analyses were performed using SPSS25.0 software to compare pre- and post-training scores. Results: Post-intervention results showed significant improvement in the cognitive function of AD patients. The total scores of MMSE, MoCA, and ADAS-cog scales increased significantly (P