TITLE:
Arterial mechanical properties after replacement or reconstruction of the aortic root
AUTHORS:
Kai Mortensen, Muhammet Aydin, Alexander M. J. Bernhardt, Verena Appenzeller, Peter N. Robinson, Jürgen Berger, Herman Reichenspurner, Yskert von Kodolitsch
KEYWORDS:
Arterial Stiffness; Aortic Valve-Sparing Reimplantation Operation; Composite Valve Grafting Operation; Marfan Syndrome
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.2 No.1,
December
31,
2011
ABSTRACT: Background: Alteration of arterial mechanical properties has adverse effects on cardiovascular disease in Marfan syndrome. Design: We compared central pulse pressure, augmentation index adjusted to a heart rate of 75 beats per minute (AIx@HR75) and pulse wave velocity in 25 Marfan patients who had under-gone an aortic valve-sparing reimplantation operation, in 15 Marfan patients after composite valve grafting operation, and in 40 age and sex-matched Mar-fan patients who had not undergone surgery. Results: Central pulse pressure, AIx@HR75 and pulse wave velocity were similar across all three patient groups. Exclusively AIx@HR75 was higher with conduit operations than in persons without any surgery (P = 0.03). Multivariate linear regression analysis documented association of AIx@HR75 with body height (P