TITLE:
Research Progress of Breast Cancer Stem Cell Stemness and Breast Cancer Recurrence
AUTHORS:
Huifang Zeng, Guanming Lu
KEYWORDS:
Breast Cancer Stem Cells, Stemness, Recurrence, Tumour Microenvironment, Drug Resistance
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.8,
August
23,
2024
ABSTRACT: Currently, breast cancer is the most common malignant tumour in Chinese women with a high incidence rate, and recurrence and metastasis are the main reasons affecting survival. Breast Cancer Stem Cells (BCSCs) are stem cells capable of continuous regeneration in vivo with strong self-renewal ability and multidirectional differentiation potential, which are highly tumourigenic and insensitive to radiotherapy and chemotherapy, and are highly susceptible to breast cancer recurrence. Therefore, exploring the stemness of BCSCs and their mechanism associated with recurrence is important for developing new therapeutic strategies, improving therapeutic efficacy, and improving patient prognosis.