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OCDE (2008) Lignes directrices n° 407 de l’OCDE pour les essais de produits chimiques, études de toxicité orale à dose répétée pendant 28 jours sur les rongeurs. 1-14.
https://www.oecd.org/fr/env/essai-n-407-toxicite-orale-a-doses-repetees-pendant-28-jours-sur-les-rongeurs-9789264070691-fr.htm

has been cited by the following article:

• TITLE: Toxicological Study of the Hydroalcoholic Extract of a Recipe of Three Plants Used in Traditional Togolese Medicine

  AUTHORS: Yao Hoinsou, Sossawè Poli, Fodoh Clefasse Koula, Luckman Gbati, Ablam Alognon, Tibanguebé Doumongue, Minyo Ega Sossa Montant, Gérard Akouétévi Toudji, Efui Holaly Gbekley, Bouraïma Djeri

  KEYWORDS: Carica papaya, Cocos nucifera, Persea americana, Toxicity, Togo

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.12 No.8, August 23, 2024

  ABSTRACT: This work consisted of assessing the toxicity of a recipe of three plants used in traditional Togolese medicine. Acute and sub-acute toxicity was assessed according to OECD chemical test guidelines n˚423 dated December 17, 2001 and n˚407 dated October 3, 2008 respectively. Cytotoxicity was assessed using the 3-(4,5-dimethylthiazolyl-2-yl-2,5-diphenyltetrazolium bromide (MTT) test. No significant toxicity was observed after 14 and 28 days, although a dose-dependent decrease in creatinemia was observed in male rats (the recipe to be used to moderate creatinine levels). Cytotoxicity was without effect on NCM 365 cells. The results obtained justify the use of the recipe in traditional medicine.