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Rosenfeld, P.J., Durbin, M.K., Roisman, L., Zheng, F., Miller, A., Robbins, G., et al. (2016) ZEISS Angioplex™ Spectral Domain Optical Coherence Tomography Angiography: Technical Aspects. In: Querques, G., Bandello, F. and Souied, E.H., Eds., Developments in Ophthalmology, S. Karger AG, 18-29.
https://doi.org/10.1159/000442773

has been cited by the following article:

• TITLE: Comparative Quantitative Analysis of Retinal Superficial Capillary Plexus in Patients with Retinal Vein Occlusion and Unaffected Fellow Eyes

  AUTHORS: Sinan Aptikadir, Nelly Sivkova

  KEYWORDS: Retinal Vein Occlusion, Optical Coherence Tomography Angiography, Superficial Retinal Capillary Plexus

  JOURNAL NAME: Open Journal of Ophthalmology, Vol.14 No.3, August 8, 2024

  ABSTRACT: Purpose: To evaluate optical coherence tomography angiography (OCT-A) data obtained from the superficial retinal capillary plexus of patients with retinal vein occlusion and comparative analysis with data registered from unaffected fellow eyes. Methods: The examined patients were classified into 2 groups: group 1—eyes with established retinal vein occlusion (n = 29) and group 2—unaffected fellow eyes of patients with retinal vein occlusion (n = 24). The scanning protocol “Angiography 3 × 3 mm” of Zeiss Cirrus HD-OCT 6000, AngioPlex Metrix was used to evaluate the retinal superficial capillary plexus. The analyzed parameters were vascular density and perfusion density, as well as the area, perimeter, and circularity of the foveolar avascular zone (FAZ). Results: The comparative analysis of FAZ parameters at the superficial capillary plexus (SCP) between group 1 (eyes with retinal vein occlusion) and group 2 (unaffected fellow eyes) showed significant results for the three parameters, respectively area (p = 0.003), perimeter (p ≤ 0.001), and circularity (p = 0.011) of FAZ. The comparative analysis of the vascular network at SCP in patients with diagnosed retinal vein occlusion and unaffected fellow eyes showed significant results for vascular density (VD) in the central (p = 0.038) and inner (p ≤ 0.001) zones as well as total VD (p ≤ 0.001) were statistically significant. Moreover, the results obtained in the study of vascular perfusion (VP) indicated significant results in the inner zone (p ≤ 0.001) and total VP (p = 0.001). Vascular perfusion in the central zone (p = 0.116) was the only parameter not to meet significant results. Conclusion: The current study observed a significant enlargement of the FAZ and loss of its circularity, along with a reduction in vascular network parameters at the superficial retinal capillary plexus level.