TITLE:
Advancements in Functional Magnetic Resonance Imaging for Persistent Postural-Perceptual Dizziness
AUTHORS:
Mengchun Zhou, Lan Zhang, Tao Yang, Qiang Tu, Tingting Hu
KEYWORDS:
Persistent Postural Dizziness, Functional Imaging, Magnetic Resonance Imaging
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.8,
August
6,
2024
ABSTRACT: Persistent postural-perceptual dizziness, defined in 2017, is a chronic functional vestibular disorder. Which is characterized by persistent dizziness, unsteadiness, and/or non-spinning vertigo. However, the exact mechanisms remain unclear. In recent years, FMRI studies have provided key insights into the pathogenesis of PPPD. This review summarized functional imaging studies of persistent postural dizziness and its predecessors in recent years and found changes in the activity and functional connectivity of important areas of visual processing, multisensory vestibular and spatial cognition in patients with PPPD. In addition, factors such as stimulation mode, personality traits, mental comorbidities and external vestibular lesions have important effects on brain functional activities and connectivity patterns, and further stratified studies on these factors are needed in the future to further clarify and draw exact conclusions on the pathological mechanism of PPPD.