TITLE:
Study of the Mineral Element Status in Sickle Cell Patients Attending the Mixed Medicine and Sickle Cell Anemia Center “Yolo Mabanga” in Kinshasa in Democratic Republic of the Congo
AUTHORS:
Misengabu Mbuyamba Nicole, Inkalaba Kasasuka Guelord, Ilunga Kabengele Alain, Kodondi Kule-Koto Fridolin
KEYWORDS:
Mineral Elements, Sickle Cell Disease, CMMASS
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.8,
August
1,
2024
ABSTRACT: Introduction: Sickle cell disease, also called sickle cell anemia, is a genotypic disorder prevalent in the black population; it is characterized by a hemolytic type anemia and can worsen following a deficiency of copper, zinc and serum iron. Methods: It was a question of evaluating the plasma status of copper and zinc by the photometric method, serum iron was measured by spectrophotometry, and finally ferritin and transferrin were measured by the immunoenzymatic method; in subjects with sickle cell disease and healthy subjects of all ages followed at the mixed medicine and sickle cell anemia center in Kinshasa (CMMASS). Results: A total of 60 subjects participated in this study. The sex ratio was 1.30; the average age of sickle cell patients was 7.4 years ± 3.8 and 27.4 years ± 5.1; for the control group, the average age was 8.2 years ± 4.2 and 29 years ± 6.7. 13.3% of children with sickle cell disease presented hypocupremia and 13.3% hypercupremia. For adults with sickle cell disease, 26.7% had hypocupremia and 13% had hypercupremia. Regarding zincemia, 67% of children and adults with sickle cell disease presented hypozincemia; 60% of child subjects with sickle cell desease demonstrated hyposideremia; in adults with sickle cell desease 20% have hyposideremia and 13% have hypersideremia. Conclusion: Our results demonstrate not only the effective presence of iron overload in adult sickle cell patients, but also an iron deficiency in controls and sickle cell patients, ignoring hemolysis.