TITLE:
Research Progress of microRNA in the Diagnosis of Tuberculous Pleurisy
AUTHORS:
Surui Chen, Xinyu Li, Jiale Chen, Yunnan Shen, Boyu Hui, Wei Wu
KEYWORDS:
Tuberculous, Pleurisy, miRNA, Diagnosis
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.7,
July
22,
2024
ABSTRACT: Tuberculosis has become a major public health and social problem threatening human health, and a large proportion of pulmonary tuberculosis patients are associated with tuberculous pleurisy (TP). Therefore, it is of great significance to find markers with high specificity and sensitivity for the rapid and accurate diagnosis and differential diagnosis of TP under the severe background of high infectivity and mortality due to the occult nature of TP. The extraction of microRNA (miRNA) from pleural effusion satisfies the characteristics of strong operability. miRNA exists not only in cells, but also in various body fluids and participates in the pathophysiological process of various diseases including infectious diseases. miRNA is a highly specific biomarker in pleural fluid in patients with TP. Therefore, this article provides a review of the research progress of mRNA in tuberculous pleurisy.