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Janech, M.G., Fitz-gibbon, W.R., Chen, R., Nowak, M.W., Miller, D.H., Paul, R.V. and Ploth, D.W. (2003) Molecular and functional characteriza-tion of a urea transporter from the kidney of the Atlantic stingray. American Journal of Physiology (Renal Physiology), 284, F996-F1005.

has been cited by the following article:

• TITLE: Living with high concentrations of urea: They can!

  AUTHORS: Francesca Trischitta, Caterina Faggio, Agata Torre

  KEYWORDS: Elasmobranch; Urea; TMA; Gills; Kidney; Rectal Gland

  JOURNAL NAME: Open Journal of Animal Sciences, Vol.2 No.1, January 5, 2012

  ABSTRACT: Marine elasmobranchs maintain their body fluid isoosmotic or slightly hyperosmotic to the external medium by the retention of large urea concentrations. This review focuses on the strategies adopted by these fishes to maintain a large outwardly direct concentration gradient of this osmolyte minimizing the loss across the main interfaces between body fluid and the external medium such as the gills, the kidney and the rectal gland, thus reducing the cost of making urea. The high plasma osmolarity, mainly main-tained by urea retention, is a challenge to volume homeostasis when fish move from seawater to water with a low salinity, since the high water permeability of branchial epithelium would cause a net flux of water into the animal. Since the renal regulation of urea retention in habitat with different salinities is crucial for the osmotic homeostasis of these species, the regulation of the activity and/or the expression of urea trans porters in renal tubules will be also discussed. In addition attention will be paid on the urea– methylamine system involved in maintaining the stability and functioning of many proteins since it is known that the high urea concentration found in marine elasmobranch fish, similar only to that found in mammalian kidney, has a destabilizing effect on many macromolecules and inhibits functions such as ligand binding.