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Feng, T., Liu, Q., Xu, Z.-Y., Li, H.-T., Wei, W., Shi, R.-C., Zhang, L., Cao, Y.-M. and Liu, S.-Z. (2023) Design, Synthesis, Herbicidal Activity, and Structure-Activity Relationship Study of Novel 6-(5-Aryl-Substituted-1-Pyrazolyl)-2-Piconilic Acid as Potential Herbicides. Molecules, 28, Article 1431.
https://doi.org/10.3390/molecules28031431

has been cited by the following article:

• TITLE: Improved Analytical Methods for Determination of Residues of Nitrapyrin and 6-Chloropicolinic Acid in Different Crop Matrices by Liquid Chromatography-Tandem Mass Spectrometry

  AUTHORS: Fabiola G. Zuno-Floriano, Riza L. Reyes-Punongbayan, Matt J. Hengel

  KEYWORDS: Herbicide, Agricultural Products, External Calibration, LC-MS/MS, Registration

  JOURNAL NAME: Journal of Agricultural Chemistry and Environment, Vol.13 No.3, July 12, 2024

  ABSTRACT: Novel analytical methods were developed for the determination of nitrapyrin and 6-chloropicolinic acid (6-CPA) residues in agricultural products. Nitrapyrin was extracted with hexane: toluene (1:1, v/v) and 6-CPA with 0.1 N sodium hydroxide (NaOH). For nitrapyrin, samples were cleaned with silica solid phase extraction (SPE) and for 6-CPA with C18 or carbon SPE. Analysis was performed by liquid chromatography-tandem mass spectroscopy (LC-MS/MS) with external calibration (0.010 to 0.0010 µg∙mL−1 for nitrapyrin and 0.0050 to 0.00025 µg∙mL−1 for 6-CPA). Recoveries for nitrapyrin and 6-CPA were 68% - 102% and 66% - 90%, respectively. Nitrapyrin was detected in celery and onion (−1) and 6-CPA in onion, mustard greens and lettuce (−1). Lower level method validation (LLMV) for nitrapyrin and 6-CPA was 0.020 µg∙g−1 and 0.050 µg∙g−1, respectively. The methods presented in this study are robust and were utilized for the registration of nitrapyrin on agricultural commodities in the United States.