Article citationsMore>>

Baumert, B.G., Rutten, I., Dehing-Oberije, C., Twijnstra, A., Dirx, M.J., Debougnoux-Huppertz, R.M., Lambin, P. and Kubat, B. (2006) A Pathology-Based Substrate for Target Definition in Radiosurgery of Brain Metastases. International Journal of Radiation Oncology, Biology, Physics, 66, 187-194.
https://doi.org/10.1016/j.ijrobp.2006.03.050

has been cited by the following article:

• TITLE: Planning Target Volume Margin in Linac-Based Stereotactic Radiosurgery for Brain Metastases

  AUTHORS: Hany S. Attallah, Radwa M. Hamed, Khaled M. EL-Shahat, Aliaa Mahmoud, Mahmoud Abdallah, Ibraheem Haggag, Emad Moustafa, Adel Yassin

  KEYWORDS: SRS, Brain Metastases, PTV

  JOURNAL NAME: Journal of Cancer Therapy, Vol.15 No.7, July 10, 2024

  ABSTRACT: Background: The treatment of brain metastases with radiotherapy has shifted to the use of Stereotactic Radio-surgery (SRS). The technical issue of expanding the treatment volume around the Gross Tumor Volume (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV margins, ranging from one to 2 mm. Material and Methods: We performed a dosimetric comparison in plans of twenty patients using three margins: PTV zero, PTV1, and PTV2. We also developed imaginary Peel volumes. These volumes are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the mean PTV volume differed significantly across the different margins (p = 0.000). The V12 of the brain significantly varied as a function of PTV margin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volume dosimetric analysis showed that the mean dose was significantly higher in the nearby normal brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosimetric analysis, expanding the GTV into a PTV by 1 mm margin is more convenient than 2 mm.