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Schiff, D., Messersmith, H., Brastianos, P.K., Brown, P.D., Burri, S., Dunn, I.F., Gaspar, L.E., Gondi, V., Jordan, J.T., Maues, J., Mohile, N., Redjal, N., Stevens, G.H.J., Sulman, E.P., van den Bent, M., Wallace, H.J., Zadeh, G. and Vogelbaum, M.A. (2022) Radiation Therapy for Brain Metastases: ASCO Guideline Endorsement of ASTRO Guideline. Journal of Clinical Oncology, 40, 2271-2276.
https://doi.org/10.1200/JCO.22.00333

has been cited by the following article:

• TITLE: Planning Target Volume Margin in Linac-Based Stereotactic Radiosurgery for Brain Metastases

  AUTHORS: Hany S. Attallah, Radwa M. Hamed, Khaled M. EL-Shahat, Aliaa Mahmoud, Mahmoud Abdallah, Ibraheem Haggag, Emad Moustafa, Adel Yassin

  KEYWORDS: SRS, Brain Metastases, PTV

  JOURNAL NAME: Journal of Cancer Therapy, Vol.15 No.7, July 10, 2024

  ABSTRACT: Background: The treatment of brain metastases with radiotherapy has shifted to the use of Stereotactic Radio-surgery (SRS). The technical issue of expanding the treatment volume around the Gross Tumor Volume (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV margins, ranging from one to 2 mm. Material and Methods: We performed a dosimetric comparison in plans of twenty patients using three margins: PTV zero, PTV1, and PTV2. We also developed imaginary Peel volumes. These volumes are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the mean PTV volume differed significantly across the different margins (p = 0.000). The V12 of the brain significantly varied as a function of PTV margin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volume dosimetric analysis showed that the mean dose was significantly higher in the nearby normal brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosimetric analysis, expanding the GTV into a PTV by 1 mm margin is more convenient than 2 mm.