TITLE:
Extra-Axial Anaplastic Pleomorphic Xanthoastrocytoma Mimicking Meningioma: A Case Report with Literature Review
AUTHORS:
Kaoutar Stitou, Ilias Zahir, Oualid Mohammed Hmamouche, Marouane Hammoud, Faycal Lakhdar, Mohammed Benzagmout, Khalid Chakour, Mohammed El Faiz Chaoui
KEYWORDS:
Anaplastic Features, BRAF, Extra-Axial, High Mitotic Rate, High Proliferation Index, Meningeal, Pleomorphic Xanthoastrocytoma
JOURNAL NAME:
Open Journal of Modern Neurosurgery,
Vol.14 No.3,
July
10,
2024
ABSTRACT: Background: A number of meningeal neoplastic lesions may radiologically and clinically simulate meningioma, include hemangiopericytomas, solitary fibrous tumors, schwannomas, hematolymphoid lesions, metastases, and others very rarely, also may clinically mimic meningiomas. Case Description: We present the case of A 28-year-old male patient, with no notable medical history, who presented with worsening headaches for 3 months, imbalance, and visual deficits, An initial MRI revealed extra-axial lesion involving the right Parieto-occipital, The tumor was hypointense on T1-weighted MR images, hyperintense signals on T2-weightedMR images, and heterogeneously enhanced suggestive of a meningioma, total resection was achieved, and the histopathological analysis confirmed the diagnosis of an angioblastic meningioma. However, 15 months later, the patient presented with the same initial visual complaints. A subsequent MRI showed lesion recurrence, leading to a second surgical intervention. The histopathological analysis confirmed the diagnosis of an anaplastic xanthoastrocytoma. Conclusion: This represents an unusual location for an anaplastic pleomorphic xanthoastrocytoma, which should broaden the differential diagnosis of extra-axial lesions.