TITLE:
Allogenic Stem Cell Transplantation and COVID-19 Antibodies: Mechanistic Insights and Recipient Concerns
AUTHORS:
Amna Umer, Asma Umer Khayam, Nasar Khan, David Lawrence Greene, Umm E. Habiba, Sabiha Shamim
KEYWORDS:
Vaccination, Stem Cell, Allogeneic, COVID, Antibodies
JOURNAL NAME:
Open Journal of Immunology,
Vol.14 No.2,
June
28,
2024
ABSTRACT: Collecting umbilical cord stem cells is widely practiced due to its numerous benefits. Over the past decade, umbilical cord stem cells (UCSCs) have shown effectiveness in treating various conditions, such as bone pathologies, neuropsychiatry disorders, hereditary diseases, and metabolic disorders. However, factors like immunization affect the quantity and quality of cord harvesting. Studies suggest that antibodies from the mother pass through the umbilical cord to protect the infant against infections. Cleaning the umbilical cord before stem cell extraction is crucial to maintain sterility and cell integrity. Vaccinating a female donor, including for COVID-19, typically does not directly affect the stem cells. Although vaccines aim to trigger an immunological response, they generally do not affect the donor’s stem cells.