TITLE:
Progress of Transmural Healing in Crohn’s Disease
AUTHORS:
Yinan Han, Xiaoping Tan
KEYWORDS:
Transmural Healing, Inflammatory Bowel Disease, Crohn’s Disease
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.5,
May
28,
2024
ABSTRACT: Recently transmural healing (TH) has become a subject of increasing interest as a potential therapeutic purpose for inflammatory bowel disease (IBD). Crohn’s disease (CD) is characterized by chronic inflammation of the gastrointestinal tract, which can involve any part of the digestive tract, and the lesions are usually discontinuous, with progressive and destructive transmural lesions that can lead to irreversible damage such as fibrotic strictures, complications such as fistulas and abscesses. Disease remission remains the primary goal of therapeutic management; however transmural healing is a very promising endpoint for monitoring treatment response. Along with small bowel imaging tests such as computed tomography scans Intestinal imaging (CTE), magnetic resonance intestinal imaging (MRE), intestinal ultrasound (IUS) and other related imaging technologies are popularized in CD diagnosis and treatment benefit. Transmural healing has been initially used in clinical practice and the correlation between its rules and long-term clinical remission has been explored.