TITLE:
A Bronchopulmonary Onset of Candidemia Revealing a Granulomatosis with Polyangiitis
AUTHORS:
Chaïmaâ Zeroual, Mina Moudatir, Khadija Echchilali, Leila Barakat, Hassan El Kabli
KEYWORDS:
Candidemia, C. glabrata, Pulmonary Candidiasis, Vasculitis, Immunodepression, Granulomatosis with Polyangiitis, Cavitary Lesions, Antifungal Therapy, Immunosuppressants
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.13 No.5,
May
8,
2024
ABSTRACT: Candidemia is defined as being a yeast infection confirmed by the presence of at least one positive Candida blood culture. It is a life threatening infection causing high mortality. The clinical signs are generally compatible with the causative agent (whether there is a deep venous catheter or not). On the other hand and according to the 2012 Revised Chapel Hill Classification, granulomatosis with polyangiitis GPA is classified as a vasculitis associated with antineutrophil cytoplasmic antibodies ANCA. It is a systemic disease characterized by the anatomopathological aspect of granuloma. We report the case of a patient who presented an atypical and a very rare revealing mode of GPA which was a bronchopulmonary candidiasis complicated by candidemia. Despite its controversy, the combination in the acute phase of antifungal treatment based on intravenous voriconazole and glucocorticoid therapy has made it possible to control candidemia and calm vasculitis.