Article citationsMore>>

Tripathi, M., Maskara, P., Sankhyan, N., Sahu, J.K., Kumar, R., Kumar, N., Ahuja, C.K., Kaur, P., Kaur, R., Batish, A. and Mohindra, S. (2021) Safety and Efficacy of Primary Hypofractionated Gamma Knife Radiosurgery for Giant Hypothalamic Hamartoma. Indian Journal of Pediatrics, 88, 1086-1091.
https://doi.org/10.1007/s12098-020-03637-w

has been cited by the following article:

• TITLE: Precocious Puberty in a 5-Year-Old Girl with a Giant Hypothalamic Hamartoma Discovered Perinatally: Case Report

  AUTHORS: Ghita Bourkadi, Sanae Habibi, Sana Abourazzak, Moustapha Hida

  KEYWORDS: Perinatally-Hypothalamic Hamartoma-Giant-Precocious Puberty

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.14 No.4, April 26, 2024

  ABSTRACT: Background: Hypothalamic hamartoma is a rare non-neoplastic lesion, typically identified in early childhood during investigations for precocious puberty and/or gelastic seizures. However, cases of diagnosis even earlier or during fetal development have been documented. Case Presentation: A newborn girl was diagnosed with hydrocephalus during pregnancy. An MRI revealed a large oval hypothalamic process, which suggested a hypothalamic hamartoma. At the age of 2, she experienced alternating crying and laughing seizures, followed by a decrease in visual acuity. Due to involvement of the optic pathways, surgery was not performed and she underwent antiepileptic medicines and gamma knife radiotherapy. At the age of 5 years and 3 months, she presented with breast development and laboratory tests confirmed central precocious puberty. Quarterly injections of GnRH agonists have since been administered with favorable results. Conclusion: Early-diagnosed hypothalamic hamartomas require close monitoring, by an experienced multidisciplinary, to promptly detect and treat potential complications, especially precocious puberty, and prevent any undesirable impact on final height.