TITLE:
Animal Model of Aortic Valve Calcification: Their Methodology Helps Us Understand Aortic Valve Calcification
AUTHORS:
Yinze Wei, Zhen Wang, Miao Chen, Liang Ma
KEYWORDS:
Animal Model, Aortic Valve Stenosis, Calcification, Cardiovascular
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.15 No.4,
April
26,
2024
ABSTRACT: Aortic valve calcification disease (CAVD) is the most prevalent degenerative valve disease in humans, leading to significant morbidity and mortality. Despite its common occurrence, our understanding of the underlying mechanisms remains incomplete, and available treatment options are limited and risky. A more comprehensive understanding of the biology of CAVD is essential to identify new therapeutic strategies. Animal models have played a crucial role in advancing our knowledge of CAVD and exploring potential treatments. However, these models have inherent limitations as they cannot fully replicate the complex physiological mechanisms of human CAVD. In this review, we examine various CAVD models ranging from pigs to mice, highlighting the unique characteristics of each model to enhance our understanding of CAVD. While these models offer valuable insights, they also have limitations and shortcomings. We propose that the guide wire model shows promise for future CAVD research, and streamlining the methodology could enhance our understanding and expand the research scope in this field.