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Piedrahita, J.A., Zhang, S.H., Hagaman, J.R., Oliver, P.M. and Maeda, N. (1992) Generation of Mice Carrying a Mutant Apolipoprotein E Gene Inactivated by Gene Targeting in Embryonic Stem Cells. Proceedings of the National Academy of Sciences of the United States of America, 89, 4471-4475.
https://doi.org/10.1073/pnas.89.10.4471

has been cited by the following article:

• TITLE: Animal Model of Aortic Valve Calcification: Their Methodology Helps Us Understand Aortic Valve Calcification

  AUTHORS: Yinze Wei, Zhen Wang, Miao Chen, Liang Ma

  KEYWORDS: Animal Model, Aortic Valve Stenosis, Calcification, Cardiovascular

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.15 No.4, April 26, 2024

  ABSTRACT: Aortic valve calcification disease (CAVD) is the most prevalent degenerative valve disease in humans, leading to significant morbidity and mortality. Despite its common occurrence, our understanding of the underlying mechanisms remains incomplete, and available treatment options are limited and risky. A more comprehensive understanding of the biology of CAVD is essential to identify new therapeutic strategies. Animal models have played a crucial role in advancing our knowledge of CAVD and exploring potential treatments. However, these models have inherent limitations as they cannot fully replicate the complex physiological mechanisms of human CAVD. In this review, we examine various CAVD models ranging from pigs to mice, highlighting the unique characteristics of each model to enhance our understanding of CAVD. While these models offer valuable insights, they also have limitations and shortcomings. We propose that the guide wire model shows promise for future CAVD research, and streamlining the methodology could enhance our understanding and expand the research scope in this field.