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Rodger, M.A., Betancourt, M.T., Clark, P., Lindqvist, P.G., Dizon-Townson, D., Said, J., et al. (2010) The Association between Factor V Leiden and Prothrombin Gene Mutation and Placental Mediated Pregnancy Complications: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. PLOS Medicine, 7, Article 1000292.
https://doi.org/10.1371/journal.pmed.1000292

has been cited by the following article:

• TITLE: Activated Protein C Resistance in Patients with Pre-Eclampsia in Lagos, Nigeria

  AUTHORS: Nosimot O. Davies, Titilope A. Adeyemo, Sunday I. Omisakin, Akaninyene A. Udousoro, Kabiru A. Rabiu

  KEYWORDS: Activated Protein C Resistance, Activated Protein C Ratio, Pre-Eclampsia

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.14 No.4, April 26, 2024

  ABSTRACT: Background: Preeclampsia is reported to complicate 2% - 8% of pregnancies globally and is an important cause of maternal and perinatal morbidity and mortality. The aetiology and pathogenesis are still poorly understood and substantial improvement has not been made in the prediction, prevention and treatment of the disease. Objective: To compare the frequency of activated protein C resistance (APC-R) in patients with pre-eclampsia to that of normotensive pregnant women and to determine the correlation between activated protein ratio (APC-ratio) and the severity of pre-eclampsia. Methodology: A cross-sectional study was carried out in 100 pre-eclamptic patients and 100 normotensive pregnant controls. The APC-ratio was determined using the modified activated partial thromboplastin time. Study participants with APC-ratio of less than 2.0 were defined as having APC-R. Data was analyzed using SPSS version 22.0. Results: Mean APC-ratio was significantly lower in pre-eclamptics (2.89 ± 1.70) compared to normotensive pregnant women (3.57 ± 1.06) (p = 0.0008) and the levels were also higher in mild (2.95 ± 1.15) compared to severe pre-eclamptics (2.62 ± 1.14). The frequency of APC-R was 26% among women with pre-eclampsia compared to 4% among normotensive controls (p = 0.000). Among 100 pre-eclamptic women 7 (21.2%) out of 33 with mild pre–eclampsia had APC-R, while 19 (28.4%) out of 67 with severe pre-eclampsia had APC-R. APC-ratio had a significant negative correlation with mean arterial blood pressure (r = −0.324; p = 0.000) and proteinuria (r = −0.379; p = 0.000) among study participants. Conclusion: The frequency of activated protein c resistance is significantly higher in pre-eclamptics compared to normotensive pregnant women and this is more pronounced in those with severe pre-eclampsia compared with those with mild disease. APC-R may therefore be used as a marker of severity in the disease.