TITLE:
Research Progress on Epigenetic Mechanism of Sarcopenia
AUTHORS:
Lijie Yang, Han Lu, Yaolei Cha, Qing Yang, Yuan Zhao
KEYWORDS:
Sarcopenia, Epigenetics, DNA Methylation, RNA Methylation, Noncoding RNA
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.4,
April
19,
2024
ABSTRACT: In recent years, sarcopenia, as a progressive muscular atrophy and weakness, has become one of the common diseases in the elderly. Although its cause is not fully understood, a growing body of research suggests that epigenetic mechanisms play an important role in the pathogenesis of sarcopenia. The purpose of this review is to summarize the current research progress in the epigenetics of sarcopenia, focusing on the role of DNA methylation, RNA methylation and non-coding RNA in the pathogenesis of sarcopenia. While exploring the epigenetic mechanism of sarcopenia, this study will also look into the application prospect of epigenetics in the treatment strategy of sarcopenia, which will provide new ideas and directions for the treatment of sarcopenia.